La maladie de Parkinson en France (serveur d'exploration)

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Correlation between the anatomical and functional human subthalamic nucleus.

Identifieur interne : 002580 ( Main/Exploration ); précédent : 002579; suivant : 002581

Correlation between the anatomical and functional human subthalamic nucleus.

Auteurs : Wieslaw Nowinski [Singapour] ; A. Thirunavuukarasuu [Singapour] ; Jimin Liu [Singapour] ; Alim-Louis Benabid [France]

Source :

RBID : Hal:inserm-00382760

Abstract

This work addresses the spatial correlation between the anatomical and functional human subthalamic nucleus (STN). The anatomical STN (A-STN), derived from the Schaltenbrand-Wahren brain atlas, is histology based. The functional STN (F-STN) is probabilistic, constructed from neuroelectrophysiological and neuroimaging data of 184 Parkinson's disease patients. The A-STN and F-STN are placed in the same space and compared in terms of mutual relative overlapping of anatomy with function. The F-STN and A-STN correlate well for medium and high probabilities of the F-STN. For probability p >or= 0.3, >95% of F-STN is inside the A-STN, and for p >or= 0.5, the complete F-STN is inside the A-STN for each left and right STN. Therefore, the F-STN for p = 0.5 can potentially be used for identification of the STN in neuroimages.

Url:
DOI: 10.1159/000097924


Affiliations:


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Le document en format XML

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